Semaphorin 3A Induces Mesenchymal-Stem-Like Properties in Human Periodontal Ligament Cells
نویسندگان
چکیده
منابع مشابه
Semaphorin 3A promotes osteogenic differentiation in human alveolar bone marrow mesenchymal stem cells.
The aim of the present study was to investigate the role of Semaphorin 3A (Sema3A) in the osteogenic differentiation of human alveolar bone marrow mesenchymal stem cells (hABMMSCs). To investigate whether Sema3A affects hABMMSC proliferation and osteogenic differentiation, a stable Sema3A-overexpression cell line was generated by infection with the pAdCMV-SEMA3A-MCS-EGFP vector. Cell counting k...
متن کاملcharacterization of mesenchymal stem cells from human dental pulp, preapical follicle and periodontal ligament
background: human dental stem cells have high proliferative potential for self-renewal that is important to the regenerative capacity of the tissue. objective: the aim was to isolate human dental pulp stem cells (dpsc), periodontal ligament stem cells (pdlsc) and periapical follicle stem cells (pafsc) for their potential role in tissue regeneration. materials and methods: in this experimental s...
متن کاملThe potential of human-derived periodontal ligament stem cells to osteogenic differentiation: An In vitro investigation
Background: Periodontal ligament stem cells (PDLSCs) are considered as a type of mesenchymal stem cell that is beneficial target for numerous clinical applications in periodontal tissue regeneration therapy. Materials and Methods: This study examined the effects of dexamethasone (Dex) on human PDLSCs in vitro. PDLSCs obtained from the roots of patient’s teeth were cultured with Dex (0....
متن کاملPeriodontal Ligament Stem Cells
Millions of people experience consequential tooth loss related to irretrievable damage of the periodontium caused by deep caries, severe periodontal diseases or irreversible trauma, resulting in a decreased quality of life. Hence, dental scientists have focused much attention on tissue engineering techniques in an effort to address this condition. The periodontium is composed mainly of two soft...
متن کاملSemaphorin 3A Shifts Adipose Mesenchymal Stem Cells towards Osteogenic Phenotype and Promotes Bone Regeneration In Vivo
Adipose mesenchymal stem cells (ASCs) are considered as the promising seed cells for bone regeneration. However, the lower osteogenic differentiation capacity limits its therapeutic efficacy. Identification of the key molecules governing the differences between ASCs and BMSCs would shed light on manipulation of ASCs towards osteogenic phenotype. In this study, we screened semaphorin family memb...
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ژورنال
عنوان ژورنال: Stem Cells and Development
سال: 2014
ISSN: 1547-3287,1557-8534
DOI: 10.1089/scd.2013.0405